primary lymphoid organs造句

• These are the two primary lymphoid organs where T cells and B cells mature.
• TdT is expressed mostly in the primary lymphoid organs, like the thymus and bone marrow.
• At this point the T cells leave the primary lymphoid organ and enter the blood stream.
• As this tolerance is dependent on encountering self-antigens during maturation, lymphocytes can only develop central tolerance towards those antigens present in primary lymphoid organs.
• Although expression is typically found to be in the primary lymphoid organs, recent work has suggested that stimulation via antigen can result in secondary TdT expression along with other enzymes needed for gene rearrangement outside of the thymus for T-cells.
• V ( D ) J recombination occurs in the primary lymphoid organs ( bone marrow for B cells and thymus for T cells ) and in a nearly random fashion rearranges variable ( V ), joining ( J ), and in some cases, diversity ( D ) gene segments.